Angry Addict

I’m hoping that by sharing this here…I don’t fucking kill some newcomer at a meeting.  I just moved back to my hometown….again.  I am starting over with doctors, therapists, etc.  I have to START OVER every time I move.  For the past 10 years I have suffered from chronic pain in my neck and my back due to a freak incident while visiting a friend at a correctional facility.  I was attacked, not only once, but twice by an inmate who assumed I had purposely “pushed” his girlfriend (which I did not).  For the last 4-5 years the major cause of pain has been from 3 bulging discs in my neck that irritate a nerve that runs from my neck and down my right arm.  It hurts every minute of every day.

I am home again because I moved to Syracuse, NY to attend college at SUNY College of Environmental Science and Forestry and because of the pain (being “treated” mind you) I could not keep up in my classes.  I attempted to hold out because this was my dream.  I was only making things worse by ending each semester with horrible grades and unfinished assignments due to time off and/or my inability to write, take notes,  read for long periods of time, and sit at a desk for hours on end…let alone getting there on a bus, lugging around all my books, trying to sit through lectures, and getting home on the bus.

I get to a place many many times where I feel helpless, hopeless and like life will never be worth living for me again (this is while being “treated”).  I am a resilient person and have been able to bounce back each time only to find myself in this place again where I feel dark, alone, and like giving up (my life).

I am 30 years old, on disability, and trying to survive for the last 10 years on $780 a month.  I am ALWAYS only JUST making ends meet.  So on top of the physical pain there is the stress of everyday expenses, not having money to just relax and have fun, and I am always pinching pennies.  When I don’t act frugally I suffer greatly from backed-up bills, lack of rent, etc.

I am also a recovering addict.

I had a few relapses over the last year after over 4 years clean.  I used from the time I was 15ish starting with marijuana and alcohol and I progressed and “graduated” to other drugs from there.  I am one of those addicts who TRULY believes I was born with this disease.  Since the day I was born I struggled and suffered emotionally and spiritually, feeling like I was alone, there was no one like me, I was going to live and die this way and no one cared or could see.  I also grew up in a situation where there was addiction and mental health constantly causing more than just minor problems in my life which only lead to more feelings of abandonment, betrayal and despair.

I felt EVERY emotion as raw as it could be felt, I took everything personally and I turned it ALL inward just hoping someday someone would magically become aware of the fucking hell I was existing in and take me away or fix me.  But then, I found drugs.  This did the trick for awhile and I even had “friends”.  This is not about the drugs though today so we will skip all of this.

I found recovery, was doing work on myself inwardly and learning to trust people, recognizing I was NOT alone and it was NOT the end of the world.  I was also dealing with chronic pain.  The fucked up shit I’m feeling today is that while everyone is telling me More Will Be Revealed, and Give it To God, and talking about the journey inwards (and wanting with all my heart to believe this)…I was held back by my constant struggle to find a solution for the daily suffering I was experiencing due to chronic pain.  To me, there was no hope, there were no solutions…sure I could be all peachy on the inside, get right with God, learn to make good decisions…and I even believe there is a Higher Power that can help fill the void I feel without the drugs in my life that I still to this day try and fill with a man to make me feel good, or busy-work, or drama.  I honestly DO believe that.

It ALWAYS comes back to this though.  I can pray my little fucking ass off, work towards solutions for the pain, see doctors, follow the right routes, be doing stepwork, staying away from vices, help newcomers, do service work, feel hope in OTHER areas of my life even sometimes feel some preliminary hope in this area, practice patience…but I DO NOT BELIEVE THAT THERE IS A HIGHER POWER WHO, BECAUSE I ALL OF A SUDDEN DECIDE TO LIVE RIGHT AND WITH ALL THE OTHER SUFFERING IN THE WORLD, WILL TAKE AWAY THE PHYSICAL PAIN THAT HAS STOLEN MY LIFE, MY HOPE, MY HAPPINESS, AND ANY CHANCE I EVER HAVE OF MOVING ON WITH MY LIFE NO MATTER WHAT ELSE I WORK ON OR HOW RIGHT WITH GOD AND THE WORLD I AM.

I get it, ok??  I am powerless.  People telling me  these things that they CANNOT identify with DOES NOT HELP!  Hello!!!!  Remember being in rehab and how it felt to have a non-addict therapist TRY and empathize with you??  It tells us in our own literature that the most powerful weapon we have…for addiction…is another recovering addict!!

So…what is a girl to do?????  Is there virtue in the fact that I suffer and have (sarcastic cutesy smiley faces, rainbows, and puppies attached) “FAITH” that everything will be ok.  Faith with the knowledge of no solution from that faith according to my own evidence and the LACK of evidence I see in other people in this area…is a lie.  Does it make me a better person to “accept” my lot in life when secretly I would rather die than to accept that the best possible life I could hope for for myself and now my unborn child is a spirited woman with so many dreams settling for $780 a month and no prospect of ever completing college or working in a meaningful job??

So uh…YEAH I want to use drugs, or men, or anything to make me feel good.  YEAH I am angry, resentful, and self-seeking…STILL.  YEAH I get how it is SO easy to place denial as a protection in front of those things that make “it all go away”, if even only for a moment (cause sometimes it TRULY is better than it not going away at all).  Yeah I get how I will justify the FUCK out of the things I do.  YEAH at this point in my life…AGAIN… I do not want to live or die.

And then, check this out, I also have a conscience that makes doing these things once I am aware of them impossible or painful if I cannot stop.  I also have a stubborn and very WILLFUL desire to, no matter what, live the BEST possible life I can live by doing what is right, not hurting other people or myself and following God’s will!!!!!

WHAT THE FUCK IS THAT?????????????  WHAT IS THAT JOKE ALL ABOUT???  WHAT A HORRIBLE FUCKING DISEASE!!!!!!!!!!!

 

Get Involved: Contact Congress — Sugarcane Ethanol, the Sweeter Alternative

Get Involved: Contact Congress — Sugarcane Ethanol, the Sweeter Alternative.

Information included in the link above to contact your members of Congress!!!!

Leading environmental officials at the U.S. Environmental Protection Agency (EPA) and in California agree: ethanol made from sugarcane is an ideal renewable fuel that can help reduce greenhouse gases while diversifying America’s energy resources. EPA has designated sugarcane ethanol as an Advanced Renewable Fuel – an important category of superior biofuels that, along with cellulosic biofuels and others, will make up 21 billion gallons of America’s fuel supply by 2022. This is equal to about 15% of today’s gasoline market. In California, the state’s air regulators have classified sugarcane ethanol as a “low-carbon” fuel that will help reduce greenhouse gas emissions from the state’s transportation sector.

What is it about sugarcane ethanol that makes the fuel so environmentally friendly?

  • Renewable – Sugarcane ethanol, unlike coal or oil, is produced from sugarcane plants that grow back year after year.
  • Sustainable – Since sugarcane only needs to be replanted every five to seven years – as a semi-perennial crop it can be harvested without uprooting the plant, its cultivation has less impact on the soil and surrounding environment. Learn more about sustainable sugarcane agriculture in Brazil.
  • Energy-Intensive – Sugarcane is highly efficient in converting sunlight, water and CO2 into stored energy.  Sugarcane produces seven times more energy compared to corn when used in ethanol production.
  • Lower Carbon Emissions – Compared to gasoline, sugarcane ethanol cuts greenhouse gases by more than 60%. That’s better than any other liquid biofuel produced today in large quantities.

In addition to these significant environmental benefits, sugarcane ethanol also is more affordable compared to other alternatives. That’s why many observers point to sugarcane ethanol as a good option for diversifying U.S. energy supplies, increasing healthy competition among biofuel manufacturers and improving America’s energy security.

 

NO MORE PYRAMID!!!

Most of the information gathered for this article came from ChooseMyPlate.gov

Some of the 2010 changes include:

Balancing Calories
  • Enjoy your food but eat less
  • Avoid oversized proportions
Foods To Increase
  • Make half your plates fruits and vegetables
  • Make at least half your grains whole grains
  • Switch to fat-free or low-fat milk
Foods To Reduce
  • Compare sodium levels in foods like soup, bread, and frozen meals
  • Drink water instead of sugary drinks

Food Groups

Grains

Any food made from wheat, rice, oats, cornmeal, barley or another cereal grain is a grain product. Bread, pasta, oatmeal, breakfast cereals, tortillas, and grits are examples of grain products.

Whole Grains –

Whole grains contain the entire grain kernel the bran, germ, and endosperm.

Refined Grains –

Refined grains have been milled, a process that removes the bran and germ. This is done to give grains a finer texture and improve their shelf life, but it also removes dietary fiber, iron, and many B vitamins.  Most refined grains are enriched. This means certain B vitamins (thiamin, riboflavin, niacin, folic acid) and iron are added back after processing. Fiber is not added back to enriched grains. Check the ingredient list on refined grain products to make sure that the word “enriched” is included in the grain name. Some food products are made from mixtures of whole grains and refined grains.

SECRET!!!:

Don’t be fooled by the”wheat” breads that do not say 100% whole grains somewhere on the package.  Caramel coloring is added to the bread to give it the wheat coloring.  They are technically allowed to call it “wheat bread” because…even white bread is wheat.

Vegetables

Any vegetable or 100% vegetable juice counts as a member of the Vegetable Group. Vegetables may be raw or cooked; fresh, frozen, canned, or dried/dehydrated; and may be whole, cut-up, or mashed.

Dark Green Vegetables

Dark green leafy vegetables provide many essential vitamins and minerals your body needs, such as vitamin A, vitamin C, and calcium.  In addition, they are also a wonderful way to get the fiber your body needs. The darker the leaves, the more nutrients the vegetable usually has.

bok choy
broccoli
collard greens
dark green leafy lettuce
kale
mesclun
mustard greens
romaine lettuce
spinach
turnip greens
watercress

Starchy Vegetables

Starchy vegetables are healthy, but they are higher in carbohydrate than other vegetables and they have more calories.

cassava
corn
fresh cowpeas, field peas, or black-eyed peas (not dry)
green bananas
green peas
green lima beans
plantains
potatoes
taro
water chestnuts

Red and Orange Vegetables

Red– Contains nutrients like lycopene, ellagic acid, Quercetin, and Hesperidin.  These nutrients reduce the risk of prostate cancer, lower blood pressure, reduce tumor growth and LDL cholesterol levels, scavenge harmful free-radicals, and support join tissue in arthritis cases.

Orange (and Yellow)– Contain beta-carotene, zeaxanthin, flavonoids, lycopene, potassium, and vitamin C. These nutrients reduce age-related macula degeneration and the risk of prostate cancer, lower LDL cholesterol and blood pressure, promote collagen formation and healthy joints, fight harmful free radicals, encourage alkaline balance, and work with magnesium and calcium to build healthy bones.

acorn squash
butternut squash
carrots
hubbard squash
pumpkin
red peppers
sweet potatoes
tomatoes
tomato juice

Beans and Peas

Legumes which are high in protein value, although their proteins are not regarded as having sufficient amounts of the amino acids required by the human body, and should, therefore, not be used as the sole source of protein foods. They are of high caloric value and they make some contributions to the mineral and vitamin content of the dietary. Peas are relatively high in vitamin A content, which is associated with many physiological functions, notably growth and dark adaptation. Both beans and peas, particularly soy beans, are good sources of vitamin B1, which is the anti-neuritic vitamin enjoying such wide attention at the present time.

black beans
black-eyed peas (mature, dry)
garbanzo beans (chickpeas)
kidney beans
lentils
navy beans
pinto beans
soy beans
split peas
white beans

Other Vegetables

Here is a link for the nutritional value of specific vegetables.

Fruits

Here is a link for the nutritonal value of specific fruits.

Dairy

All fluid milk products and many foods made from milk are considered part of this food group. Most Dairy Group choices should be fat-free or low-fat. Foods made from milk that retain their calcium content are part of the group. Foods made from milk that have little to no calcium, such as cream cheese, cream, and butter, are not. Calcium-fortified soymilk (soy beverage) is also part of the Dairy Group.

*Selection Tips

Choose fat-free or low-fat milk, yogurt, and cheese. If you choose milk or yogurt that is not fat-free, or cheese that is not low-fat, the fat in the product counts against your maximum limit for “empty calories” (calories from solid fats and added sugars).
divider
If sweetened milk products are chosen (flavored milk, yogurt, drinkable yogurt, desserts), the added sugars also count against your maximum limit for “empty calories” (calories from solid fats and added sugars).
divider
For those who are lactose intolerant, smaller portions (such as 4 fluid ounces of milk) may be well tolerated. Lactose-free and lower-lactose products are available. These include lactose-reduced or lactose-free milk, yogurt, and cheese, and calcium-fortified soymilk (soy beverage). Also, enzyme preparations can be added to milk to lower the lactose content. Calcium-fortified foods and beverages such as cereals, orange juice, rice milk, or almond milk may provide calcium, but may not provide the other nutrients found in dairy products.

Protein Foods

All foods made from meat, poultry, seafood, beans and peas, eggs, processed soy products, nuts, and seeds are considered part of the Protein Foods Group. Beans and peas are also part of the Vegetable Group.  Select a variety of protein foods to improve nutrient intake and health benefits, including at least 8 ounces of cooked seafood per week. Young children need less, depending on their age and calories needs. The advice to consume seafood does not apply to vegetarians. Vegetarian options in the Protein Foods Group include beans and peas, processed soy products, and nuts and seeds. Meat and poultry choices should be lean or low-fat.

*Selection Tips

Choose lean or low-fat meat and poultry. If higher fat choices are made, such as regular ground beef (75 to 80% lean) or chicken with skin, the fat counts against your maximum limit for empty calories (calories from solid fats or added sugars). divider
If solid fat is added in cooking, such as frying chicken in shortening or frying eggs in butter or stick margarine, this also counts against your maximum limit for empty calories (calories from solid fats and added sugars). divider
Select some seafood that is rich in omega-3 fatty acids, such as salmon, trout, sardines, anchovies, herring, Pacific oysters, and Atlantic and Pacific mackerel.divider
Processed meats such as ham, sausage, frankfurters, and luncheon or deli meats have added sodium. Check the Nutrition Facts label to help limit sodium intake. Fresh chicken, turkey, and pork that have been enhanced with a salt-containing solution also have added sodium. Check the product label for statements such as “self-basting” or “contains up to __% of __”, which mean that a sodium-containing solution has been added to the product. divider
Choose unsalted nuts and seeds to keep sodium intake low.

 

Malicious, Spammy, Scamming, Likejacking or Just Downright Annoying Apps on Facebook

So…I’m sick of warning everyone individually about all the shitty, spammy, and annoying apps that are out there in Facebook World.  So I am going to start this guide.

If there is a Web of Trust warning there will be a photo of the Web of Trust Scorecard and a link to read the comments people left about why they gave it such a bad warning.

What is Web of Trust you ask??

Web of Trust is the leading website reputation rating tool and one of Mozilla’s most popular add-ons. Our safe surfing tool uses an intuitive traffic-light style rating system to help you see which websites are trusted when you search, surf and shop online.

WOT ratings are powered by a global community of millions of trustworthy users who have rated millions of websites based on their experiences. The WOT add-on provides reputation ratings to search results when you use Google, Facebook, Twitter, Yahoo!, Bing, Wikipedia and other popular sites, helping you protect your computer and personal information. Your online email account – Google Mail, Yahoo! Mail and Hotmail is also protected.

Here is the link to add it on to your Mozilla Firefox Browser:

https://addons.mozilla.org/en-US/firefox/addon/wot-safe-browsing-tool/

If it has not been rated yet, or they have been tricky and are hiding under the general “facebook apps” links, I will just put a picture and a description as to the issue.

fb5.apps.friendsy.us

Friend Buzz is the general name that this app lies under.  What it looks like on your wall is this:

Here is another app from Friend Buzz with bad ratings:

The ratings for this are the worst in every category.  Here is the link to WOT:

http://www.mywot.com/en/scorecard/fb5.apps.friendsy.us

So in general, just don’t add anything having to do with Friend Buzz.

Fun in Your Name – (Created Via-> Http://apps.facebook.com/fun)

 

About the Developer:  Senang Solutions specialized in Internet Social Networking Applications.

Developer Name:  http://www.senang-solutions.com

It is difficult to find a rating on Web of Trust.  Here is some info I found at this website:

http://www.spotnblog.com/facebook-scam-fun-in-your-name/

“Do not install the following Facebook App: Fun in Your Name! by – Senang Solutions specialized in Internet Social Networking Applications.

This App is what you call Likejacking, a form of clickjacking, is a malicious technique of tricking users of a website into posting a Facebook status update for a site they did not intentionally mean to “like”.

Stay away from these kind of “like” comments or Apps, because the people behind it earns loads of money on you being stupid. In worst case you will end of with a Malware infected PC.”

More info about clickjacking:

http://en.wikipedia.org/wiki/Clickjacking

Warning about Likejacking:

http://www.readwriteweb.com/archives/likejacking_takes_off_on_facebook.php

How to avoid Likejacking:

http://techie-buzz.com/social-networking/avoid-likejacking-clickjacking.html

socialappsmail.com

Friend Rank or 20 Top Friends

Also developed Top Loves and probably some others

Here are some photos of what they look like on your wall and requesting permission.  NOTE HOW MUCH INFO THEY WANT FOR SUCH AN INSIGNIFICANT APP!!!

Here is the Web of Trust Ranking for this developer in general:

Link to the rating:

http://www.mywot.com/en/scorecard/socialappsmail.com

Here is a link to this developer’s fucked up Privacy Policy:

http://www.socialappsmail.com/privacy-policy

Info on Stalker Apps –

These are the apps in which you are promised to be shown who looks at your profile the most. First of all, if you have clicked on these you are so gullible your mama should have just shoved you back in rather than expose the world to your stupidity. Here is a link for info about these:

http://arstechnica.com/web/news/2011/01/those-facebook-stalker-apps-they-dont-work-so-avoid-them.ars

Beware the following messages and/or wall postings from Facebook friends:

Example #1:

I’ve just seen who checks me out the most here on Facebook! You can see who stalks you too!

http://todayurl.com/stalker

Example #2:

I just saw who STALKS me here on Facebook. You can see who creeps around your profile too!

http://todayurl.com/stalker

Example #3:

I just saw who CREEPS around my pics the most here on Facebook. You can see who stalks you too!

http://todayurl.com/stalker

These are all variants of the same scam. If you click on the link, you’re taken to a page that requests your permission to access private information. If you allow it to do so, the message immediately reposts itself on all your friends’ walls and you’re prompted to fill out a phony questionnaire.

What it won’t do is show you your Facebook “stalkers” or reveal the names of people who’ve visited your Facebook page or viewed your photos. The whole thing is a ruse to trick more people to installing the useless app and clicking through to survey pages.

Then there is the “Slap Myself in the Face for Being So Fucking Stupid” Link that people just have to see:

Girl Killed Herself After Father Posted On Her Wall

I will add more as I find them!! Feel free to pass this note around and tag your idiotic friends who need to see this cause they swear up and down the app is fine. Also, private message me any that YOU find that I have missed.

Update: Although this one is not new I just saw it on a friend’s page.

The Dislike Button

Here is a link with some information about this one:

http://mashable.com/2011/05/17/facebook-dislike-button-scam/

Possbile Cancer Cure: With Links to Primary Literature on Dichloroacetate

Dichloroacetate

via Scientists cure cancer, but no one takes notice — Health & Wellness — Sott.net.

Full article at above link.

This was something that I did not want to blog about at face value.  I typed the drug name into Google Scholar to see what primary literature I could find on the subject.  Here is some real information I have found:

British Journal of Cancer

http://www.nature.com/bjc/journal/v99/n7/full/6604554a.html

Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer

E D Michelakis1, L Webster1 and J R Mackey2

  1. 1Department of Medicine, University of Alberta, Edmonton, Canada
  2. 2Department of Oncology, University of Alberta, Edmonton, Canada

Correspondence: Dr ED Michelakis, Department of Medicine, University of Alberta Hospital, 8440-112 Street, Edmonton, AB, Canada T6G 2B7; E-mail: evangelos.michelakis@capitalhealth.ca

Received 18 December 2007; Revised 28 April 2008; Accepted 4 July 2008; Published online 2 September 2008.

————————————————————————————

“The unique metabolism of most solid tumours (aerobic glycolysis, i.e., Warburg effect) is not only the basis of diagnosing cancer with metabolic imaging but might also be associated with the resistance to apoptosis that characterises cancer. The glycolytic phenotype in cancer appears to be the common denominator of diverse molecular abnormalities in cancer and may be associated with a (potentially reversible) suppression of mitochondrial function.

The generic drug dichloroacetate is an orally available small molecule that… increases the flux of pyruvate into the mitochondria, promoting glucose oxidation over glycolysis.”

Free Patents Online

http://www.freepatentsonline.com/y2009/0118370.html

Method of Treating Cancer using Dichloroacetate

Kind Code: A1
Abstract: “The invention relates to the use of dichloroacetate and chemical equivalents thereof for the treatment of cancer by inducing apoptosis or reversing apoptosis-resistance in a cell Preferably, the dosage is 10-100 mg/kg Preferably, sodium dichloroacetate is used. The dichloroacetate may optionally be given in combination with a pro-apoptotic agent and/or a chemotherapeutic agent Preferably, the cancers treated are non-small cell lung cancer, glioblastoma and breast carcinoma.”
Inventors: Michelakis, Evangelos (Edmonton, CA)
Archer, Stephen (La Grange, IL, US)
Application Number: 11/911299
Publication Date: 05/07/2009
Filing Date: 04/11/2006
Primary Class: 514/557
Other Classes: 600/300
International Classes: A61K31/19; A61B5/00; A61P35/00; A61K31/185; A61B5/00; A61P35/00

Description:

This patent application claims priority from U.S. Provisional Patent Application No. 60/669,884 filed Apr. 11, 2005, the content of which is hereby incorporated by reference herein.

FIELD OF THE INVENTION

The invention relates to the use of dichloroacetate and obvious chemical equivalents thereof in the treatment of cancer. Related uses and diagnostic and screening methods are also included in one aspect of the present invention.

BACKGROUND OF THE INVENTION

Most cancers are characterized by a resistance to apoptosis that makes them prone to proliferation and resistant to most cancer therapies. Most of the available cancer treatments aim to induce apoptosis but are highly toxic. There are two main categories of apoptosis: the receptor-mediated and the mitochondria-dependent apoptosis. Mitochondria-dependent apoptosis is not very well studied and only recently have the mitochondria been viewed as anything more than an organelle that produces energy. As such there is a need for a cancer therapy that can overcome apoptosis resistance in cancer cells.

SUMMARY OF THE INVENTION

A cell can become resistant to apoptosis in a variety of ways one of which is altering its metabolism and having hyperpolarized mitochondria. Since apoptosis is initiated by depolarization of mitochondria, the more hyperpolarized a mitochondrion is, the further it is from the depolarization threshold and the more resistant it is to the initiation of apoptosis.

In one embodiment the present inventors have surprisingly found that one can modulate mitochondrial function to treat cancer. In one embodiment, the present invention provides a method for inducing apoptosis in cancer. In another embodiment, the inventors provide a method for inducting apoptosis in cancer but normal cells. In another embodiment, the invention provides a method of reversing apoptosis resistance in cancer cells, such as cancer cells with hyperpolarized mitochondria. In one embodiment, the method comprises administering to cancer cells, in one embodiment cells having or suspected of having hyperpolarized mitochondria, an effective amount of dichloroacetate or salts thereof or obvious chemical equivalents thereof.

In one embodiment, the dichloroacetate or obvious chemical equivalent thereof is administered in combination with another pro-apoptotic agent and/or chemotherapeutic agent, and/or other cancer therapy.

In one embodiment, the invention provides a method for inducing apoptosis and/or reversing apoptosis resistance in a cancer cell, comprising administering to the cell an effective amount of dichloroacetate or obvious chemical equivalent thereof. In another embodiment, the invention provides a method for inhibiting proliferation of cancer cells, comprising administering to the cells an effective amount of dichloroacetate or obvious chemical equivalent thereof. In another embodiment, the invention provides a method of decreasing survivin in a cancer cell, comprising administering to the cell an effective amount of dichloroacetate or obvious chemical equivalent thereof. In another embodiment, the invention provides a method of increasing Kv1.5 protein in a cancer cell comprising administering to the cell an effective amount of dichloroacetate or obvious chemical equivalent thereof. In another embodiment, the invention provides a method of increasing AIF in a cancer cell comprising administering to the cell an effective amount of dichloroacetate or obvious chemical equivalent thereof. In another embodiment, the invention provides a method of increasing H 2 O 2 in a cancer cell comprising administering to the cell an effective amount of dichloroacetate or obvious chemical equivalent thereof. In another embodiment, the methods of the invention cancer cells, but not normal or non-cancerous cells are affected by the treatment with dichloroacetate or obvious chemical equivalent thereof.

In one embodiment, the present invention provides a method for treating a cancer. In another embodiment, the invention provides a method of treating a cancer associated with hyperpolarized mitochondria. In another embodiment the invention provides a method of treating cancer by restoring mitochondrial membrane potential (ΔΨm) (essentially depolarizing the hyperpolarized cancer cell mitochondria). This molecular metabolic therapy is accomplished by administering to a patient in need thereof a therapeutically effective amount of dichloroacetate or obvious chemical equivalent thereof. In another embodiment, the invention provides a use of dichloroacetate or obvious chemical equivalent thereof in the treatment of cancer.

In one embodiment, the dichloroacetate is a salt of dichloroacetic acid. In another embodiment, the dichloroacetic acid is a sodium salt of dichloroacetic acid.

In one embodiment, the cancer to be treated using the DCA or obvious chemical equivalent thereof is selected from the group consisting of: non-small cell lung cancer, glioblastoma and breast carcinoma.

In another embodiment, the dichloroacetate, or obvious chemical equivalent thereof, is administered in the form of a pharmaceutical composition comprising dichloroacetate or obvious chemical equivalent thereof and a pharmaceutically acceptable carrier. In yet another embodiment the invention provides a use of dichloroacetic acid or dichloroacetate or obvious chemical equivalent thereof in the preparation of a medicament or pharmaceutical composition for the treatment of cancer, such as a cancer associated with hyperpolarized mitochondria. In yet another embodiment, the dichloroacetate, or obvious chemical equivalent thereof, is administered orally.

In yet another embodiment, the dichloroacetate is administered in a water-based formulation. In one embodiment the water-based formulation of DCA comprises 0.0075 g of DCA/l to 7.5 g of DCA/l). In another embodiment the dichloroacetate or obvious chemical equivalent thereof is administered at a total daily dose of ˜25-50 mg/kg bid of dichloroacetate. In another embodiment the dose is 10-100 mg/kg given twice a day is administered to the patient. In one embodiment the dose is 25-50 mg bid.

In another embodiment, the invention constitutes a method for determining whether a cancer is associated with hyperpolarized mitochondria, which would predict its therapeutic response to dichloroacetate or obvious chemical equivalents thereof or similar compounds. In one embodiment such method comprises administering an effective amount of dichloroacetate, or chemical equivalent thereof to a cancer tissue sample from a patient and measuring its apoptosis sensitivity and mitochondrial membrane potential using confocal microscopy or flow cytometry. This diagnostic test would determine whether the individual patient could benefit from dichloroacetate or other therapies that cause apoptosis through similar mechanism.

Other objects, features and advantages of the present invention will become apparent from the following detailed description. It should be understood, however, that the detailed description and the specific examples while indicating preferred embodiments of the invention are given by way of illustration only, since various changes and modifications within the spirit and scope of the invention will become apparent to those skilled in the art from this detailed description.

Get Control of your Private Information!

Hear Us Now : a project of Consumers Union:.

Send a message to your representative through the above link.

Bills have been introduced that will put you in control of your personal information while online or on your smartphone!

Now we need to get these online privacy bills passed, and we need consumers like you to weigh in. Opposition is expected to be strong, since online tracking of your private information is big business!

This latest bill would require companies to honor your decision if you do not want to be tracked online. And it would hold tracking companies accountable if they go against your wishes. The rules also would apply to smartphones, too.